Bone morphogenetic protein 3


Bone morphogenetic protein 3

Bone morphogenetic protein 3 (osteogenic), also known as BMP3 or osteogenin, is a human gene.cite web | title = Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=651| accessdate = ]

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

It is highly expressed in fractured tissues.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dickinson ME, Kobrin MS, Silan CM, "et al." |title=Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. |journal=Genomics |volume=6 |issue= 3 |pages= 505–20 |year= 1990 |pmid= 1970330 |doi=
*cite journal | author=Tabas JA, Zasloff M, Wasmuth JJ, "et al." |title=Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. |journal=Genomics |volume=9 |issue= 2 |pages= 283–9 |year= 1991 |pmid= 2004778 |doi=
*cite journal | author=Paralkar VM, Nandedkar AK, Pointer RH, "et al." |title=Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17281–4 |year= 1990 |pmid= 2211625 |doi=
*cite journal | author=Rosen V, Wozney JM, Wang EA, "et al." |title=Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone. |journal=Connect. Tissue Res. |volume=20 |issue= 1-4 |pages= 313–9 |year= 1990 |pmid= 2612162 |doi=
*cite journal | author=Wozney JM, Rosen V, Celeste AJ, "et al." |title=Novel regulators of bone formation: molecular clones and activities. |journal=Science |volume=242 |issue= 4885 |pages= 1528–34 |year= 1989 |pmid= 3201241 |doi=
*cite journal | author=Faucheux C, Ulysse F, Bareille R, "et al." |title=Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation. |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 3 |pages= 787–93 |year= 1998 |pmid= 9434787 |doi= 10.1006/bbrc.1997.7792
*cite journal | author=Daluiski A, Engstrand T, Bahamonde ME, "et al." |title=Bone morphogenetic protein-3 is a negative regulator of bone density. |journal=Nat. Genet. |volume=27 |issue= 1 |pages= 84–8 |year= 2001 |pmid= 11138004 |doi= 10.1038/83810
*cite journal | author=Jin Y, Lu HB, Liong E, "et al." |title=Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. |journal=Histol. Histopathol. |volume=16 |issue= 4 |pages= 1013–9 |year= 2002 |pmid= 11642720 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kloen P, Di Paola M, Borens O, "et al." |title=BMP signaling components are expressed in human fracture callus. |journal=Bone |volume=33 |issue= 3 |pages= 362–71 |year= 2004 |pmid= 13678778 |doi=
*cite journal | author=Kang Q, Sun MH, Cheng H, "et al." |title=Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. |journal=Gene Ther. |volume=11 |issue= 17 |pages= 1312–20 |year= 2004 |pmid= 15269709 |doi= 10.1038/sj.gt.3302298
*cite journal | author=Chen AL, Fang C, Liu C, "et al." |title=Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage. |journal=J. Orthop. Res. |volume=22 |issue= 6 |pages= 1188–92 |year= 2004 |pmid= 15475196 |doi= 10.1016/j.orthres.2004.02.013
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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