Cytochalasin E


Cytochalasin E
Cytochalasin E[1]
Identifiers
CAS number 36011-19-5
PubChem 5458385
EC number 252-835-7
Jmol-3D images Image 1
Properties
Molecular formula C28H33NO7
Molar mass 495.56 g mol−1
Hazards
EU classification T+
R-phrases R26/27/28 R63
S-phrases S28 S36/37 S45
Main hazards Toxic
 YesY E (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cytochalasin E, a member of the cytochalasin group, is an inhibitor of actin polymerization in blood platelets. It inhibits angiogenesis and tumor growth. Unlike cytochalasin A and cytochalasin B, it does not inhibit glucose transport.

Because of its antiangiogenic effect, cytochalasin E is a potential drug for age-related macular degeneration, a kind of blindness caused by an abnormal proliferation of blood vessels in the eye.[2]

References

External pages

Cytochalasin E from Fermentek



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Look at other dictionaries:

  • Cytochalasin B — Other names Phomin Identifiers …   Wikipedia

  • Cytochalasin D — Other names Zygosporin A; Cytohalasin D; Lygosporin A Ide …   Wikipedia

  • cytochalasin B — cytochalasin B. См. цитохалазин В. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • cytochalasin B — cytochalasin used to examine the role of microfilaments in the morphology and physiology of cells; it causes microfilaments to disappear by inhibiting the assembly of actin filaments, thus blocking numerous cell processes, e.g., cytokinesis,… …   Medical dictionary

  • Cytochalasin — Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology,… …   Wikipedia

  • Cytochalasin — Cy|to|cha|la|sin [↑ cyto griech. chálasis = Erschlaffung], das; s, e: Sammelbez. aus Schimmelpilzkulturen für isolierte ↑ Mykotoxine, die inhibitorisch auf versch. Zellfunktionen wirken. Die C. sind tricycl. Makrolide mit einem 11 bis 14… …   Universal-Lexikon

  • cytochalasin — noun Etymology: cyt + Greek chalasis slackening + English 1 in Date: 1966 any of a group of metabolites isolated from fungi (especially Helminthosporium dematioideum) that inhibit various cell processes …   New Collegiate Dictionary

  • cytochalasin — noun Any of several related fungal metabolites that have an effect on cytokinesis while not affecting karyokinesis …   Wiktionary

  • cytochalasin — cy·to·cha·la·sin .sīt ō kə lā sən n any of a group of metabolites isolated from fungi (esp. Helminthosporium dematioideum) that inhibit various cell processes * * * cy·to·chal·a·sin (si″to kalґə sin) any of a group of fungal… …   Medical dictionary

  • cytochalasin — n. type of metabolite derived from fungi (used to hinder production of microfilaments and thereby stops cellular processes that depend upon microfilaments) …   English contemporary dictionary


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