- Treatment-resistant depression
Treatment-resistant depression or refractory depression is a term used in clinical psychiatry to describe cases of
major depressive disorderthat do not respond to at adequate courses of least two antidepressants. [cite journal |author=Wijeratne, Chanaka, Sachdev, Perminder |year=2008|title=Treatment-resistant depression: critique of current approaches. |journal=Australian and New Zealand Journal of Psychiatry |volume=42 |pages=751-62 |pmid=18696279]
Treatment of refractory depression has traditionally most commonly involved
electroconvulsive therapyand use of non-standard medications, but new technologies such as transcranial magnetic stimulationare being studied as a safer alternative. Treatment of refractory depression may also involve more invasive interventions, such as vagus nerve stimulation.
The term was first coined with the development of the concept in 1974.
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