- Tetraiodothyronine 5' deiodinase
Tetraiodothyronine 5' deiodinase is an
enzyme. The amino acid selenocysteineis one of its constituentparts.
It creates the active form of
triiodothyronine(T3) from thyroxine(T4) and is one of three selenocysteine-containing iodothyronine deiodinases that work in concert to guarantee adequate local (in the peripheral tissues) and systemic (from the thyroid gland) levels of the active thyroid hormone T(3). It is known as D1. It also is capable of deactivating T3 by reduction to T2. [ [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147892&rn=1 OMIM - DEIODINASE, IODOTHYRONINE, TYPE I; DIO1 ] ]
The other two deiodinases are known as D2 and D3. D2 is the primary activator from T4 to T3 (found mostly in the thyroid,
brainand testis), while D3 is the primary inactivator from T4 and T3 (found mostly in fetal tissue and placenta).
Wikimedia Foundation. 2010.
Look at other dictionaries:
Thyroglobulin — (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as colloid . Thyroglobulin should not be confused with Thyroxine binding globulin, a carrier protein responsible… … Wikipedia
Propylthiouracil — Drugbox IUPAC name = 6 propyl 2 sulfanyl pyrimidin 4 ol CAS number=51 52 5 ATC prefix=H03 ATC suffix=BA02 ATC supplemental= PubChem=657298 DrugBank=APRD00297 C = 7 | H = 10 | N = 2 | O = 1 | S = 1 molecular weight = 170.233 g/mol bioavailability … Wikipedia
hormone — hormonal, hormonic /hawr mon ik, moh nik/, adj. /hawr mohn/, n. 1. Biochem. any of various internally secreted compounds, as insulin or thyroxine, formed in endocrine glands, that affect the functions of specifically receptive organs or tissues… … Universalium