7,12-Dimethylbenz(a)anthracene Identifiers CAS number PubChem ChemSpider ChEBI ChEMBL Jmol-3D images Image 1 Properties Molecular formula C20H16 Molar mass 256.34104 Melting point
Hazards R-phrases S-phrases Main hazards T (Toxic) (what is: /?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
7,12-Dimethylbenz(a)anthracene is an immunosuppressor and a powerful organ-specific laboratory carcinogen. Also known as 7,12-dimethylbenz[α]anthracene or DMBA, this substance is widely used in many research laboratories studying cancer. DMBA serves as a tumor initiator by making necessary mutations. Tumor promotion can be induced with treatments of TPA (12-O-tetradecanoylphorbol-13-acetate) in some models of two-stage carcinogenesis. This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.
- ^ 7,12-Dimethylbenz(a)anthracene at Sigma-Aldrich
- ^ Miyata M, Furukawa M, Takahashi K, Gonzalez FJ, Yamazoe Y. (2001) Mechanism of 7, 12-Dimethylbenz[a]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ. Jpn J Pharmacol 86:302-309. Link
- ^ Sung YM, He G, Fischer, SM. (2005) Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development. Cancer Res 65:9304-9311
Wikimedia Foundation. 2010.
Look at other dictionaries:
712-dimethylbenz[a]anthracene — 7,12 di·meth·yl·benz[a]an·thra·cene (di meth″əl benz anґthrə sēn) 9,10 dimethyl 1,2 benzanthracene; a highly carcinogenic polycyclic aromatic hydrocarbon produced during incomplete combustion of carbonaceous materials. It is… … Medical dictionary