Nico-N was developed by South Korean scientist and professor Hyun-Won Kim of the University of Yonsei’s College of Medicine. Nico-N ingredients include Chinese quince, dried orange peel, mulberry leaf, green tea, ginkgo nut, liquorice root, apple, platycodon, lemon, celery and Chinese matrimony vine.[1] Nico-N was treated in the form of chewing gum to 36 healthy male smokers with at least 2 years of smoking history. Urine analysis showed that cotinine concentration of smokers treated with Nico-N increased dose dependently compared to the non-treated control group. Cotinine, a nontoxic metabolite of nicotine, could be removed from the body in urine. Increase of the cotinine production from the smokers treated with Nico-N indicates the detoxification effect of Nico-N against nicotine.[2]


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